A Meta-Analysis of the Efficacy and Safety of Xinmailong Injection in the Treatment of Chronic Heart Failure Combined with Various Drugs

doi:10. 3969/j. issn. 2096-2266. 2021. 10. 003

Abstract

Abstract:

Objective： To further evaluate the efficacy and safety of Xinmailong injection in the treatment of chronic heart failure（CHF）. Methods： This study searched PubMed， the Cochrane Library，CNKI and other databases from the establishment of the database to 31 December 2019 for studies related to Xinmailong injection and various drugs in the treatment of CHF. Meta-analysis was carried out with RevMan 5.3 software， and indicators such as overall clinical efficacy， blood brain natriuretic peptide （BNP）， and left ventricular ejection fraction（LVEF）， ect. were included. Results： A total of 21 studies were included， and Meta-analysis showed that compared with the control groups， the Xinmailong groups can significantly reduce the patients' BNP， left ventricular enddiastolic dimension（LVEDD）， left ventricular end systolic diameter（LVESD）， C-reactive protein（CRP） levels and the total score of TCM syndromes， increase LVEF， 6 minutes' walking distance（6MWD） and cardiac index（CI）， and improve the total clinical efficacy （P< 0.05）. There was no significant difference in the incidence of adverse reactions between the Xinmailong groups and the control groups（P=0.15>0.05）. Conclusion： On the basis of conventional treatment， compared with the application of other therapeutic drugs for CHF， Xinmailong injection alone or in combination has a significant effect on CHF， but the safety aspect needs to be further confirmed by a more comprehensive， accurate and objective large sample study.

Key words:

"> chronic heart failure">； Xinmailong injection">； Meta-analysis

CLC Number:

R285

Fan Yuxin, Li Xinyao, Peng Fang.

A Meta-Analysis of the Efficacy and Safety of Xinmailong Injection in the Treatment of Chronic Heart Failure Combined with Various Drugs [J]. Journal of Dali University, 2021, 6(10): 14-.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/10. 3969/j. issn. 2096-2266. 2021. 10. 003

http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/Y2021/V6/I10/14

References

〔1〕陈佳斌，秦佳枫，赵钢.慢性心力衰竭的中西医发病机制及其治疗进展〔J〕.中西医结合心脑血管病杂志，2019，17（3）：378-380.

〔2〕陈晓军，叶靖，郑燕慧，等.心脉隆注射液对急性心力衰竭患者QT间期离散度及心率变异性的影响〔J〕.亚太传统医药，2019，15（5）：155-158.

〔3〕张瑜,李利华.慢性心力衰竭患者及主要照顾者的照护能力现状及影响因素〔J〕.大理大学学报，2021，6（4）:71-79.

〔4〕张家美，尚亚东，吴晓蓉，等.心脉隆注射液治疗慢性心力衰竭临床疗效的Meta分析〔J〕.中国全科医学，2014，17 （12）：1388-1393.

〔5〕吴佳铭，尹中，杜立建.心脉隆联合多巴酚丁胺治疗慢性心功能不全疗效观察〔J〕.现代中西医结合杂志，2012，1（28）：3091-3092.

〔6〕嵇诚，朱文龙，张立新，等.心脉隆注射液加曲美他嗪对慢性心力衰竭的治疗作用研究〔J〕.系统医学，2019，4（5）：75-77.

〔7〕赵广阳，郭锎，袁婧玮，等.美托洛尔联合心脉隆注射液对慢性心力衰竭患者心功能和炎性因子的影响〔J〕.中国现代医生，2019，57（20）：51-53.

〔8〕许宇飞，刘克强.心脉隆注射液联合左西孟旦治疗慢性心力衰竭的临床研究〔J〕.中国初级卫生保健，2019，33（12）：120-121.

〔9〕中华医学会心血管病学分会，中华心血管杂志编辑委员会.慢性心力衰竭诊断治疗指南〔J〕.中华心血管病杂志，2007，35（12）：1076-1095.

〔10〕 JESSUP M， ABRAHAM W T， CASEY D E， et al. 2009 Focused Update： ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults： A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines： Developed in Collaboration with the International Society for Heart and Lung Transplantation 〔J〕. Circulation，2009，

119（14）：1977-2016.

〔11〕 JADAD A R， MOORE R A， CARROLL D， et al. Assessing the Quality of Reports of Randomized Clinical Trials： Is Blinding Necessary？〔J〕. Control Clin Trials，1996， 7（1）：1-12.

〔12〕 LIN L. Comparison of Four Heterogeneity Measures for Meta-Analysis〔J〕. J Eval Clin Pract，2020，26（1）：376-384.

〔13〕王建河.心脉隆注射液治疗慢性心力衰竭疗效及安全性分析〔J〕.世界最新医学信息文摘，2019，19（23）：145.

〔14〕骆金中，张雪然，朱茗瑞.心脉隆注射液治疗老年慢性心力衰竭的疗效〔J〕.实用中西医结合临床，2018，18（4）：14-16.

〔15〕原建华.心脉隆注射液治疗慢性心力衰竭的有效性评析〔J〕.北方药学，2019，16（5）：174.

〔16〕陈汝兴，袁灿兴，徐蓉娟，等.心脉龙治疗慢性充血性心力衰竭的临床研究〔J〕.医学理论与实践，1999（11）：633-636.

〔17〕陈荣红.心脉隆注射液单用或联合硝普钠治疗慢性心衰的疗效观察〔J〕.中西医结合心血管病电子杂志，2016，4（26）：30-31.

〔18〕邓素珍，黄初劭，钟芸舒.心脉隆注射液联合左旋卡尼汀治疗慢性充血性心力衰竭的疗效观察〔J〕.临床医药实践，2018，27（4）：270-272.

〔19〕薛铮，吕新湖，段延章，等.心脉隆注射液联合卡维地洛治疗慢性心力衰竭临床研究〔J〕.现代中西医结合杂志，2012，21（23）：2549-2550.

〔20〕张静，陈彩萍，过晶，等.心脉隆注射液联合重组人脑钠肽治疗慢性心衰患者的临床观察〔J〕.现代生物医学进展，2018，18（22）：4285-4289.

〔21〕刘勇，王昕.心脉隆注射液联合参芍胶囊治疗88例慢性心力衰竭患者的临床研究〔J〕.数理医药学杂志，2019，32（11）：1699-1700.

〔22〕赵洋，李艳，王智刚，等.心脉隆注射液联合环磷腺苷葡胺治疗慢性心力衰竭的临床研究〔J〕.中西医结合心脑血管病杂志，2018，16（22）：3315-3318.

〔23〕许恩文，方昱，张庆斌，等.心脉隆注射液联合米力农治疗慢性充血性心力衰竭的临床研究〔J〕.现代药物与临床，2018，33（9）：2276-2280.

〔24〕刘群.心脉隆联合阿托伐他汀治疗慢性心衰患者的疗效观察〔J〕.华夏医学，2018，31（5）：96-99.

〔25〕杨宁，王恒亮，司定然.心脉隆注射液联合多巴胺治疗慢性心力衰竭的疗效观察〔J〕.现代药物与临床，2017，32（5）：796-799.

〔26〕叶科峰，孙佩，张伟，等.心脉隆注射液治疗老年慢性心功能不全的疗效观察〔J〕.中西医结合心脑血管病杂志，2017，15（19）：2428-2430.

〔27〕李慧婷，薛恩忠.心脉隆注射液联合磷酸肌酸钠治疗慢性心力衰竭的临床研究〔J〕.现代药物与临床，2017，32（11）：2116-2119.

〔28〕张海燕.心脉隆注射液联合托拉塞米、多巴酚丁胺治疗慢性心力衰竭的疗效观察〔J〕.中西医结合心脑血管病杂志，2015，13（12）：1411-1413.

〔29〕惠慧，吴光鹏.心脉隆注射液联合芪苈强心胶囊治疗慢性心力衰竭的临床观察〔J〕.中西医结合心脑血管病杂志，2017，15（22）：2869-2872.

[1]	Lu Ang, Yuan Shimeng, Zhang Chenggui, Ai Zhiqiong, Wu Xiumei. Application of Mixed Linear Model in QSAR Study of Flavonoids [J]. Journal of Dali University, 2021, 6(10): 6-.
[2]	Liu Luyun, Pu Zhoufang, Dai Jiakui. Analysis of the Use of Enteral and Parenteral Nutrition Drugs in Elderly Patients [J]. Journal of Dali University, 2021, 6(10): 25-.
[3]	Luo Chunyu, Li Yafei, Liu Qi. Study on the Correlation between Enterobacter cloacae and Body Mass Index of College Students [J]. Journal of Dali University, 2021, 6(10): 28-.
[4]	Li Yafei, Luo Chunyu, Liu Qi. Isolation and Identification of Lactic Acid Bacteria with Strong Inhibitory Effects Against Enterobacter cloacae [J]. Journal of Dali University, 2021, 6(10): 32-.
[5]	Sun Wenwen, Li Fengxian, Yin Yirui, A Zhoucun. Study on the Association between SPATA48 Gene Polymorphism and Male Oligospermia [J]. Journal of Dali University, 2021, 6(10): 37-.
[6]	Guan Yunfei, Shi Hongbo, Tan Yunbo. Comparison of Clinical Effects of TEP and TAPP on Unilateral Inguinal Hernia [J]. Journal of Dali University, 2021, 6(10): 46-.
[7]	Li Jiepeng, Luo Yong, Li Jianjun, Xiao Yukun. A Case Report and Literature Review of Epithelioid Sarcoma of Testicular Sheath [J]. Journal of Dali University, 2021, 6(10): 53-.
[8]	Zhang Guohui, Jin Yanling, Chen Kunqian, Li Fawang, Xie Kui, Chen Rong. Clinical Application of Balloon Occlusion of Bilateral Common Iliac Artery in Patients with Pernicious Placenta Previa under Ultrasound Guidance [J]. Journal of Dali University, 2021, 6(10): 56-.
[9]	Jiang Guomeng, LiaoYing, Zhang Guomei, Liu Qingqing. Application of Transesophageal Three-Dimensional Echocardiography in the Diagnosis of Cardiac Diseases [J]. Journal of Dali University, 2021, 6(10): 60-.
[10]	He Zhengzheng, Sun Jun, Wang Li, Yang Yuqi. Correlation Analysis of Peripherally Hematic Factors among AIDS Patients with Liver Damage [J]. Journal of Dali University, 2021, 6(10): 67-.
[11]	Zhao Weidong, Zhang Zihua, Li Xuemei, He Yingchun, Hu Shenghe, Kong Shan. Exploration of the Reform of the Process Assessment System of "Laboratory Diagnostics" Based on the "Questionnaire Star" Platform [J]. Journal of Dali University, 2021, 6(10): 72-.
[12]	Chen Qian, Cheng Huirong, Huang Hao, Yang Jiao, Feng Wanjun, Wen Weihua. Effects of Arsenic and Its Metabolites on cIAP1、cIAP2 and XIAP Genes in A549 Cells [J]. Journal of Dali University, 2021, 6(10): 76-.
[13]	Zhang Yuzhen, Yang Weihong, Zhang Hailin, Feng Yun, Zhou Jihua, Pan Hong, Han Xi. Evaluation on the Construction and Practice of Canine Rabies Surveillance System in Chuxiong Yi Autonomous Prefecture， Yunnan Province [J]. Journal of Dali University, 2021, 6(10): 82-.
[14]	Zhao Guifeng, Dong Wei, Jiang Yangping, Li Zengye, Luan Yuquan, Fu Yanfen. Multi-Center Application Study of the Best Evidence for Low-to-Medium Ｆlow Oxygen Therapy [J]. Journal of Dali University, 2021, 6(10): 87-.
[15]	Wu Limei. Experience of Conservative Treatment and Nursing of Closed Kidney Injury Caused by Trauma [J]. Journal of Dali University, 2021, 6(10): 91-.